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Doxazosin mesylate is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water 0.

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Control of high blood pressure should be part of comprehensive cardiovascular risk managementincludingas appropriatelipid controldiabetes managementantithrombotic therapysmoking cessationexerciseand limited sodium intakeMany patients will require more than one drug to achieve blood pressure goalsFor specific advice on goals and managementsee published guidelinessuch as those of the National High Blood Pressure Education Program’s Joint National Committee on PreventionDetectionEvaluationand Treatment of High Blood PressureJNC

Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

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